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PROJECT CRAINARCHIONS
DISCLAIMER
This research project has been assigned the label: TOP SECRET.
All affiliated members are required to sign a Non Disclosure Agreement.
Violation of the NDA will result in terminal prosecution and immediate contract termination.
This research project has been assigned the label: TOP SECRET.
All affiliated members are required to sign a Non Disclosure Agreement.
Violation of the NDA will result in terminal prosecution and immediate contract termination.
PROJECT LEAD: DZUNDZA, ERIKA
PROJECT STAFF: PENDING
ASSIGNED LABS: APPLIED BIOLOGY LABORATORIES (BSL-4); NECROSCOPY
PROJECT ABSTRACT:
Headcrabs are a volatile pest that have plagued humanity ever since their inception at the Black Mesa Incident in 2001. WHO and CDC estimates that globally 866 million individuals have succumbed to the infestation up until this day, with an estimated annual count of 430 thousand individuals.
Upon conception, the host is maintained in a comatose state, bordering a braindead scenario. While the different stages have been observed, no laboratory has been able to solve the mystery pertaining to the transformation in men. Different research groups have been able to identify alternating mirrors of inflammatory and anti-inflammatory responses correlating with helminth infections in mice, ruminants and non-human primates. These studies have worked with organ-based derivatives from different headcrab species, as human testing has been highly controversial and is in stride with the Lisbon Convention of 2005 on Xenolithic and Xenopathological discoveries, innovations and applications.
This project will mainly focus on assessing the blood and microbiome profiles in humans, prior to and during infection, where different stages will be evaluated. For this to succeed, human test subjects will be subjected to in-house generated, inbred headcrab species, raised under specific-pathogen free conditions. Based on non-human primate models, a virological influence could be the result of triggering immune and developmental pathways upon infection. Following total transformation, both the individual and headcrab will be sacrificed, a full body autopsy will be conducted to assess the conditions that have contributed to drastic changes to the human and headcrab host.
The outcomes of this research will be pivotal in understanding the pathological scenarios that evoke the host re-programming responses down to the level of adult stem cells, bone marrow composition, tissue structures and microbiome interactions. Any unnatural, isolated compounds will be studied in detail. Based on these, gain-of-function research will be conducted to identify headcrab ecological parameters that may be relevant in their own evolutionary selection strategies. In the end, different antidota may be developed that can aid as a first response to headcrab-associated infections and infestations. This will allow us, Black Mesa, to take responsibility for our actions. The gained understanding will assist in developing eradication and control strategies.
PROJECT MEMBER CALL
The project calls for all interested parties within the Sector C Science, Engineering and Medical staff to forward their interest to project lead: Dr. Erika Dzundza.
